Released on March 20, 2024, this third edition of the handbook introduces the use of targeted next-generation sequencing (tNGS) for drug susceptibility testing, an update from the previous version published in 2021. This method offers a more efficient way to detect resistance to TB medications directly from patient samples. The new handbook represents a global effort by WHO and its partners to enhance the quality of TB diagnosis, contributing to the goal of eliminating tuberculosis by 2030.
Associate Professor Timothy Walker and Dr Phan Trieu Phu from TB Group (OUCRU Ho Chi Minh) were part of the systematic review team that contributed to the development of this handbook. Their involvement reflects OUCRU’s ongoing efforts to contribute to global health improvements through research.
The handbook is designed to support the practical application of WHO’s recommendations by healthcare professionals managing TB. It includes guidance on the introduction and scale-up of new diagnostic tests, updated diagnostic algorithms, and budgetary considerations.
This latest edition emphasizes the shift towards using tNGS over traditional, culture-based testing methods. This change is expected to speed up the identification of drug-resistant TB, facilitating more timely treatments for those affected.
OUCRU’s collaboration with WHO on this project illustrates its dedication to supporting infectious disease research with practical applications. It is an example of how OUCRU’s work can have impact on health policy and practice far beyond the immediate region.
The WHO operational handbook on tuberculosis can be downloaded here.
