Funder
US NIH
Principal Investigators
Scientific Leadership Group with representatives from 7 consortia including the 5 CEIRS centres
OUCRU Principal Investigator
Associate Professor Rogier van Doorn
Locations
Ha Nam and Hanoi, Viet Nam
Status
Until May 2022
This study aims to conduct human surveillance for SARS-CoV-2 and influenza virus at eight sites across the Southern Hemisphere and equatorial regions. Each of these sites has an established research relationship with one of the five Centers of the CEIRS Network. Each site has the clinical and laboratory infrastructure needed to support enrollment, data and sample collection, and analysis of virological and serological parameters using qPCR and ELISA assays, respectively. Each site is furthermore able to ship biospecimens to US-based CEIRS laboratories for more in-depth analyses. One of the sites is the Ha Nam community household cohort that is led by OUCRU Hanoi and the National Institute of Hygiene and Epidemiology, Viet Nam.
Major knowledge gaps remain around the natural history of infection, the spectrum of disease, risk factors for severe outcomes and the magnitude, quality and longevity of immune responses. To address these gaps, systematic and in-depth analyses of viral load, clinical outcomes, and immune responses of infected individuals are rapidly needed. We propose to undertake such an effort. To give context to the results obtained and better understand their implications for human health, we will examine SARS-CoV-2 and influenza virus infection in parallel.
The study aims to enroll 40 index cases with influenza and 40 index cases with COVID-19. We will follow-up patients in 12 months. According to the recommended schedule (10 sampling time points), acutely infected participants will be more intensively sampled to determine virus infection dynamics and kinetics, humoral and cellular immune responses, co-infections, and host gene expression.
