This study is a randomised, open label, controlled adaptive platform trial that will be conducted in low-risk patients with COVID-19, recruited from outpatient COVID-19/ Acute Respiratory Infection (ARI) clinics or through other approved facilities. Previously healthy patients 18 to 60 years old with early symptomatic COVID-19 and without co-morbidities are eligible for the study. Enrolled patients are followed up daily for 7 days and then on Day 10 and Day 14. Phone follow-up is conducted on Day 28 and Day 120. The interventions in this study currently includes Nitazoxanide, Paxlovid (Nirmatrelvir/Ritonavir), Metformin and Atelotrelvir/Ritonavir.