Principal Investigators
Dr Anuraj Shankar
Dr Rina Agustina, Faculty of Medicine University of Indonesia
RDT-IgM/IgG-positive tests were associated with infection (OR 10.8, 95% CI 4.43 to 26.4, p<0.001) with an area under the curve (AUC) of 0.708% and 50% sensitivity, 91.5% specificity, 30.8% positive predictive value (PPV) and 96.1% negative predictive value (NPV).
RDT results combined with age, gender, contact history, symptoms and comorbidities increased the AUC to 0.787 and yielded 62.5% sensitivity, 87.0% specificity, 26.6% PPV and 96.9% NPV.
SARS-CoV-2 RDT-IgM/IgG results integrated with other predictors increased test sensitivity by 25% indicating the approach may be an affordable tool for epidemiological surveillance for population-based Covid-19 exposure and current infection, especially in groups with outbreaks or high transmission.
This may provide an affordable option for surveillance as RT-PCR is sensitive but costly, and antigen-based RDTs are cheap but of low sensitivity, and both detect current infection but not exposure, but SARS-CoV-2 IgM/IgG RDTs detect exposure but with poor sensitivity for current infection.
